By Sara Walker, Luis J. Jara, Ronald Asherson
This ebook is among the first to guage the function of Steroids in autoimmune rheumatic illnesses from the fundamental mechanisms to the scientific involvements and specializes in the significance of steroidal hormones within the pathogenesis and therapeutical administration of the autoimmune rheumatic illnesses. specifically, the chapters examine the mechanisms of motion and the involvement of adrenal steroids (glucocorticoids) within the neuroendocrine immune approach, together with the results on aged. The perturbations of the HPA axis as resource of altered steroidal sythesis might be mentioned and regarding a few fascinating pathological stipulations frequently complicating the autoimmune rheumatic ailments susch as psychosis or fibromyalgia. about the position of gonadal steroids (sex hormones), numerous chapters will speak about medical and epidemiological evidences in their position, in addition to their results as hazard elements in autoimmune rheumatic ailments, together with a piece in Pediatrics. *The ultimate factor comparing the position of Steroids in autoimmune rheumatic illnesses from the fundamental mechanisms to the scientific involvements*Documents the most recent learn and point out fresh and coming new therapeutical-biological ways to the therapy*The publication will current therapeutical views in regards to the new glucocorticoids, and the consequences of organic medicines on their synthesis
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Extra info for Endocrine Manifestations of Systemic Autoimmune Diseases, Volume 9 (Handbook of Systemic Autoimmune Diseases)
Arthritis Rheum. 47, 202–209. , et al. 2004. Pregnancy, cytokines and disease activity in systemic lupus erythematosus. Arthritis Rheum. 51, 989–995. , et al. 1992. Plasma sex hormones and aromatase activity in tissues of patients with systemic lupus erythematosus. Lupus 1, 191–195. H. 2007. Gender as risk factor for autoimmune diseases. J. Autoimmun. 28, 1–6. , et al. 2005. Effects of testosterone, 17-beta estradiol, and downstream estrogens on cytokine secretion from human leukocytes in the presence and absence of cortisol.
K. 2006. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc. Natl. Acad. Sci. USA 103, 9970–9975. , Sakane, T. 1996. Hormones and lupus: defective dehydroepiandrosterone activity induces impaired interleukin-2 activity of T lymphocytes in patients with systemic lupus erythematosus. Ann. Med. Interne (Paris) 147, 248–252. , Shoenfeld, Y. 2005. The neuroendocrine-immune interactions in systemic lupus erythematosus: a basis for understanding disease pathogenesis and complexity.
Anti-estrogens, receptor modulators, antagonist metabolites, and M. Cutolo et al. 18 androgenic compounds) to treating this family of diseases. In conclusion, sex hormones play a role in the genesis of autoimmunity and future research may provide a therapeutic approach that is capable of altering disease pathogenesis, rather than targeting disease sequelae (Ackerman, 2006). Key points Estrogens enhance humoral immunity, and androgens and progesterone are natural endogenous immune suppressors.